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Key limitations of current evidence include: Relatively short follow-up periods (typically 35 years) in randomised trials, whereas pancreatic cancer may take years to develop Potential for detection bias, as patients on GLP-1 therapy may undergo more frequent medical monitoring Difficulty accounting for all confounding factors in observational studies Despite these limitations, the weight of current evidence does not support a causal link between GLP-1 receptor agonist use and pancreatic cancer development

Lancet 402(10397):203234

As Henry told me, there has been an extraordinary change in consumer understanding of health. Covid made diet feel more directly linked to wellbeing, ultra processed foods moved from a niche debate into the mainstream, and AI made it easier for people to ask basic questions about what they should eat

If youre experiencing severe nausea, vomiting, inability to keep food down, abdominal pain, or sudden vision loss, get medical help immediately