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This stratified approach avoids the one-size-fits-all assumptions that have constrained past indication extension attempts and provides a clearer, evidence-led path to expanding GLP-1 use where it is biologically and clinically justified.

Manufacturing capacity constraints have exacerbated the situation, and as of mid-2024 still continue to affect Victoza and Ozempic production

39 In the arcuate hypothalamic nucleus, activation of GLP-1 RAs stimulates pro-opiomelanocortin neurons, promoting satiety through -melanocyte-stimulating hormone and inhibiting hunger-associated neurons expressing neuropeptide Y and agouti-related peptide

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It is scheduled for a second reading in the House of Representatives on Monday