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The STEP-HFpEF DM studies include individuals with obesity and heart failure, but also with DM2 [130]

Recently, these medications have become extremely popular, in part due to offlabel use

Beneficial Cardiometabolic Effects: They do not reduce CVD risk per se but are likely to contribute to favorable lipid profiles, lower blood pressure, and reduced inflammation, consequently potentially supporting heart health indirectly

However, it did lead to a reduction in TSH levels, in agreement with the findings of the study conducted by Kseolu et al

Participants titrating up to the highest dose of 36 milligrams lost an average of 12.4% of their initial body weight (27.3 pounds) over the course of the 72-week study