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Relative contraindications include recurrent pancreatitis, gastroparesis, or ongoing unexplained gastrointestinal symptoms

In addition, semaglutide even has the potential to indirectly improve other weight-related health concerns

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Antiplatelet therapy: For those with prior clotting history and elevated homocysteine

Between June and July 2025, when the formulary change was implemented, switching from AOM tirzepatide increased, while patients with an active supply of AOM semaglutide showed stable or even slightly reduced switching during the same period, consistent with its designation as the preferred option