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This stratified approach avoids the one-size-fits-all assumptions that have constrained past indication extension attempts and provides a clearer, evidence-led path to expanding GLP-1 use where it is biologically and clinically justified.

Lund A, Vilsboll T, Bagger JI et al (2011) The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes

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