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A compelling area for future research is to investigate whether GLP-1-RAs modulate taste perception in part by altering the expression or signaling of leptin or cholecystokinin (CCK) in taste bud cells, creating an integrated hormonal milieu that fine-tunes taste sensitivity based on energy status

Second, patients in a caloric deficit may enter mild ketosis, which produces a distinct acetone-like breath odour

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When you eat and blood glucose rises, GLP-1 signals the pancreas to release insulin , which helps lower blood sugar

Subsequently, in the large randomised placebo-controlled FIDELIO-DKD trial including adults with type 2 diabetes and CKD, finerenone reduced the risk of the primary kidney outcome (a composite of kidney failure, sustained eGFR decline 40% or kidney death) by ~20% [69]