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One possibility is that GLP-1R endocytosis is required for agonist uptake by the brain via hypothalamic tanycytes, as described for leptin 65

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2011 Apr 16;377(9774):1341-52

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These legal claims accuse Novo Nordisk and Eli Lilly of not sufficiently warning users about the risk of serious side effects, such as gastroparesis (a condition that slows stomach emptying), intestinal obstruction, and additional gastrointestinal harm linked to these drugs