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However, the translation of GM-related metabolites from animal studies to clinical application faces challenges, such as the selection of metabolites, the safety and efficacy of application, and the determination of the appropriate application time and dosage (Liao et al., 2021

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Nature 471 , 597601 (2011)

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An effective treatment might require either utilization of multiple drugs which target the individual pathological processes which underlie the neurodegenerative disease or the use of a single agent which could influence multiple pathological processes