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Think of it like generic versus brand-name medications, except compounding happens before a generic version officially exists

Platelet counts less than 100,000/mm3 occurred in 2% of women with axillary node-negative, estrogen-receptor positive breast cancer who received adjuvant tamoxifen (n = 1422) compared with 1% of women who received placebo (n = 1437) following primary surgery in a randomized, double-blind study (the NSABP B-14 study)

They are useful, but they cannot answer every practical question

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Non-arteritic anterior ischemic optic neuropathy (NAION) is a rare but serious condition that affects the optic nerve and can cause sudden, painless vision loss
