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Comparing Semaglutide to Other PCOS Weight-Loss Options Metformin is a first-line PCOS medication that improves insulin sensitivity and supports modest weight loss (2-3 kg on average)

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5 Improved antioxidant status has been linked to better clinical outcomes in AP, suggesting that oxidative stress is involved in the early stages of the condition

At the cellular level, the mechanisms underlying leptin resistance induced by high leptin levels involve decreased sensitivity of the leptin signaling pathway and a saturation effect on leptin receptors (LEPR)

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