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(Cardiab) Tirzepatide Side Effects: What to Expect While Tirzepatide is generally well-tolerated, some individuals may experience side effects: Gastrointestinal Issues: Nausea, vomiting, and diarrhea are the most commonly reported adverse effects, particularly during the dose-escalation phase

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All three tirzepatide doses were found to be superior to placebo for both outcomes (Figure 2)