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Step 8: Start treatment with coaching support

Niazi and Chatham list several common symptoms that occur when starting GLP-1s or with dose adjustments: Nausea or vomiting Diarrhea or constipation Heartburn or bloating Fatigue Dehydration Muscle loss Some patients may also experience hair thinning with higher doses for prolonged periods, especially when paired with low-calorie intake

Funding Eli Lilly and Company, Indianapolis, IN, USA, funded this study and paid the Rapid Service Fee

139 Although generally well tolerated, meta-analysis of 14 clinical trials suggests that long-acting GLP-1RAs (eg, semaglutide, tirzepatide) are associated with lower rates of gastrointestinal side-effects, particularly nausea and vomiting, compared to short-acting agents (Table 2)

Because some of these people cant get GLP-1s from ethical practitioners, theyre getting them from friends or from places like medi-spas that dont know their medical history and arent going to follow up closely with them if there are side effects