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The relevance to humans is not fully established, but people with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use these medications

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Their results demonstrated that those who received semaglutide experienced an average weight reduction of 16.0% after 68 weeks, compared to 5.7% for those receiving placebo

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Suppression of food intake by Glp1r/Lepr- coexpressing neurons prevents obesity in mouse models

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