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Description
In general, DPP-4 inhibitors are effective at promoting moderate lowering of A1C and are associated with few adverse events
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Some, like liraglutide, had chemical tweaks and those fatty acid chains that made them stick to albumin

Medication Interactions (Do This Before You Buy It) Berberine can interact with medications, including through effects on drug-metabolizing enzymes (notably CYP3A4 and CYP2D6) and transport proteins

Mov Disord (2014) 29:158390

thus, their activation may lead to various nephroprotective effects
