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Biomarker Factors That Influence Your Tapering Timeline Individual metabolic markersincluding fasting glucose, insulin resistance indices (HOMA-IR), lipid panels, and GLP-1 receptor sensitivityshape how quickly you can reduce doses

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But Susan Swithers, PhD, professor of behavioral neuroscience at Purdue University and lead author of the review, says that that can't explain away everything these studies find

Maintaining a consistent interval between doses is important for keeping a steady level of the medication in your system

Moreover, several effective T2D therapies, such as metformin and berberine, have been reported to be able to restore the abundance of SCFA-producing bacteria 33