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In addition, AOPPs upregulate the Wnt/-catenin pathway through the receptor for advanced glycation end-products (RAGE) receptor, contributing to podocyte dysfunction [60]

It is important to note that receptor desensitization, feedback suppression, and compensatory signaling are by no means unique to peptidesthese phenomena are well documented for small-molecule drugs, including beta-blockers, opioids, and statins

However, CIs for many sensitivity analyses crossed the null (OR = 1), particularly in MR-Egger, which is known to have lower statistical power due to its reliance on stronger assumptions (e.g., Instrument Strength Independent of Direct Effect)

Cardiol Clin (2014) 32(1):2132, vii

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