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When a plateau occurs, switching to a different GLP-1 compound with a different mechanism of action may reignite weight loss

For a fuller treatment of these metabolic-health outcomes, see the key findings on retatrutide for managing obesity and metabolic health

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The GLP-1R is expressed in many tissues, including pancreatic islets, the central nervous system, lung, kidney, heart, intestine, and also on immune cells ( When secreted by L cells, GLP-1 either functions in an endocrine manner, being released into the blood stream where it is rapidly inactivated by DPP-4 with a half-life of about 2 min, or exerts paracrine effects like stimulating neurons

They may occur when patients start a GLP-1 agonist or increase their dose, and some can go away on their own over time