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Retatrutide and Sermorelin: Can You Take Them Together Safely

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GIP may enhance weight loss by directly targeting its receptor in the central nervous system to regulate appetite, enhancing GLP-1s anorectic action, and reducing drug-induced nausea in order to improve the tolerability of and compliance to GLP-1 receptor agonists [45]

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However, GR also is involved in increasing blood glucose (Undesirable in diabetic patients), meaning this needs to be offset by corresponding decreases in blood glucose via GLP1R