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But for some people, the side effect profile makes it unsustainable

Tirzepatide tends to produce more GI side effects at equivalent weight loss levels, which is another reason why pushing drug concentrations higher through five-day dosing is particularly risky with this medication compared to its competitors

Head-to-Head Efficacy: Tirzepatide Wins 22% vs 15% Weight Loss The most robust head-to-head comparison comes from the SURPASS-2 trial, a 40-week, phase 3 study of 1,879 adults with type 2 diabetes, published in the N Engl J Med

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