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Epidemiologic data suggest that a sustained 5 mmHg reduction in systolic blood pressure correlates with approximately 10% lower risk of major cardiovascular events and 7% reduction in all-cause mortality, though it's important to note that cardiovascular outcome trials for tirzepatide are ongoing and definitive cardiovascular benefit has not yet been established

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Blocking SIRT2 counteracts these effects and lowers the bacterial load in vivo , suggesting that SIRT2 could serve as a potential target for host-directed immunotherapy (183)

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