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Description
Medications like orforglipron (an oral, non-peptide GLP-1 agonist), survodutide (a dual glucagon/GLP-1 agonist), and CagriSema (combining cagrilintide with semaglutide) are advancing through clinical trials
In clinical trials, it lowered HbA1c by 1.5 to 2.5 percentage points depending on dose and baseline levels
This may suggest off-label prescribing of GLP-1s approved for T2D when GLP-1s approved for overweight and obesity are unavailable
In total, your kidneys produce about 1-2 quarts of urine a day
Many people need to use them long term, combined with lifestyle changes, to keep the weight off.
