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Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study Nature Medicine 2019;25:1096-1103

Essential Supplements for Bone Protection A targeted supplement regimen can make a significant difference in maintaining bone density: Calcium + Vitamin D3 Daily requirement : 1,000-1,200mg calcium and 2,000-5,000 IU vitamin D3 Best forms : Calcium citrate (more easily absorbed than calcium carbonate), vitamin D3 (cholecalciferol) Timing : Split calcium doses throughout the day for better absorption Vitamin K2 Daily requirement : 100- 200 mcg Function : Directs calcium to your bones rather than soft tissues and blood vessels Forms : MK-7 form has better bioavailability than MK-4 Magnesium Daily requirement : 320-420mg daily Forms : Magnesium glycinate or malate for better absorption and less digestive discomfort Benefits : Works synergistically with calcium and vitamin D Collagen Peptides Daily requirement : 10-15g Function : Provides the protein matrix upon which bone mineralization occurs Bonus : Also supports skin, hair, and joint health 2

How GLP-1 Medications Alter Glucose Metabolism and Fungal Risk GLP-1 agonists lower blood glucose by enhancing insulin secretion and reducing glucagon

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Despite being incomplete ( Table 4 ), the available data on genotype-phenotype correlation suggests that individuals with PWS who have the del15q genetic subtype often have a higher BMI compared to other genetic subtypes