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Real-world comparison of GLP-1 and metformin for PCOS: low one-year adherence, differing costs, side effects, and benefits of combination therapy.

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We used version 2 of the Cochrane risk-of-bias tool for randomised trials to assess risk of bias for the primary outcome

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The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut enteroendocrine cells and brain preproglucagon (PPG) neurons, which respectively define the peripheral and central GLP-1 systems