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Most gastrointestinal side effects such as nausea and early satiety peak during the dose-escalation phase and substantially improve within 48 weeks as the body adapts to the medication

Satoh, N

Precision medicine approaches (genetics, omics, and machine-learning models) are promising but remain largely exploratory and require external validation and standardization prior to routine clinical implementation

Single-Agent GLP-1 Therapy Remains the Clinical Standard Evidence from the SUSTAIN and SURMOUNT clinical trials demonstrates that monotherapy with either tirzepatide or semaglutide produces sustained weight reductions of 1522% when properly dosed over 68 weeks

17 Given the temporal relationship reported by some prospective studies, changes in ovarian hormones are obvious candidates to explain the possible association between perimenopause and depressive symptoms