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Description
Despite the growing use of these medications, there is still limited understanding of why patients are unable to continue them or choose to discontinue them
Interestingly, these effects could be partially blocked by co-administration of the GLP-1R antagonist exendin 939, and completely abrogated by surgical vagotomy [97] - further reinforcing the importance of central GLP-1R activity, and its influence on hepatic lipid metabolism
Before initiating any GLP-1 treatment during perimenopause, comprehensive medical evaluationincluding blood glucose, lipids, kidney function, and cardiovascular historyshould be conducted
Diabetes Care 44 , 13851392 (2021)
The fenfluramine component was identified as the primary culprit, but the association left a lasting shadow over phentermine as well
