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Especially regarding the central nervous system, the expression of GLP-1 receptors in reward-related regions, such as the hypothalamus, amygdala, nucleus accumbens, paraventricular nucleus, ventral tegmental area, locus coeruleus, and brain stem [21] may suggest a possible association between reward learning and symptoms like anhedonia in diseases such as depression

n = 39 in the conventional arm) who completed 5.4 years of median follow-up underwent vibration-controlled transient elastography (FibroScan) to provide evidence of steatosis (controlled attenuation parameter (CAP)) and fibrosis [liver stiffness measurement (LSM)], while 42 participants (25 in conventional and 17 in triple therapy arms) eventually underwent MRI-PDFF to estimate liver fat content [128]