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Animal models have mapped specific target cell types to downstream restitution programs

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RF-409 elicits insulin-like signaling with altered receptor-proximal phosphoregulation and temporal dynamics To compare signaling elicited by RF-409 and insulin, C2C12-IR cells( 41 ) were treated with 100 nM of both ligands and analyzed by LCMS-based phosphoproteomics at early (10 min) and later (60 min) time points( 47 ) (Supplementary Table 1)

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