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Semaglutide is a GLP-1 receptor agonist it mimics a gut hormone that signals fullness, slows stomach emptying, and helps regulate blood sugar

The most frequent trigger is eating too much or eating too quickly after the dose increase

By the time most adults reach their 40s and 50s, growth hormone levels have dropped significantly from their youthful peaks

While skin irritation is not listed as a primary side effect in most clinical trials, patient reports and dermatological literature suggest a subset of users experience increased skin reactivity, dryness, or localized inflammation

At the end of the study, the scientists found that a very low-calorie diet and the combination of a very low-calorie diet and semaglutide led to significantly greater reductions in body weight and fat mass than semaglutide alone