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Boehringer Ingelheim / Zealand Pharma (ZLDPF): Survodutide (aka BI 456906) [44] [44] In a placebo-controlled study evaluating the GLP1R/GR dual agonist (Obesity Indication), patients received weekly subcutaneous injections of 4.8mg for a duration of 46 weeks

In the diabetes group, patients on semaglutide had a fourfold increased risk of NAION compared to those on other treatments

The lower incidence of breast cancer was seen across both cohorts: 35.1 percent lower odds in the full analysis and 30.5 percent lower odds in the matched cohort

Evidence and rationale The data supporting this recommendation are derived from the management of nonsurgical patients taking GLP-1 RAs who have severe symptoms related to the drugs

Methods We conduct a retrospective case control study using data taken from the U.S