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For current practice, the most defensible use of GLP-1RAs is as a time-bounded metabolic optimization strategy in women with meaningful obesity/insulin-resistance burden, with reproductive endpoints interpreted as potential downstream gains rather than guaranteed direct effects (17, 111, 112, 124)

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offspring effects The limited data from preclinical and human studies on GLP1RA use during pregnancy suggest a complex interplay between effects on maternal and offspring health, and there are currently no data at all about short-term (i.e

A small number of patients reported headache and general malaise

In the ongoing trial, scientists have been testing whether the procedure can stimulate the growth of new, healthy tissue and result in a sustained metabolic reset