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The combination of metformin and GLP-1 RAs, via complementary mechanisms and improved leptin sensitivity, translates into greater weight loss success response and reduced GLP-1RA-related adverse events, particularly with concurrent initiation of both agents

You just have to be patient. LoGerfo agrees that managing expectations is essential

Fatty liver & lipids Investigated in trials for liver-fat reduction and broad metabolic and lipid changes

Weight loss injections such as semaglutide (Wegovy) and tirzepatide (Zepbound) can produce significant weight reduction without structured exercise programs, though the FDA has approved them as adjuncts to reduced-calorie diet and increased physical activity

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