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In addition, the relative inexperience of GSK in marketing diabetes drugs may have contributed to the poor sales

This 'start low, go slow' approach helps mitigate gastrointestinal side effects, which are typically most pronounced during the initial weeks of therapy

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In the previously discussed clinical practice study, in patients with T2D, proactive reduction in premeal insulin doses at initiation of pramlintide was also shown to reduce the incidence of hypoglycemia