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Starting with a microdose approach and finding the lowest effective dose is one strategy for long-term sustainability

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When to hold at 7.5 mg versus continuing to escalate Not everyone needs to reach 10 mg or higher

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Tumor necrosis factor- (TNF-): TNF- is an important pro-inflammatory cytokine that plays a critical role in the development and progression of MASLD

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The ethics committee at each investigative site approved the trial, and all patients provided written informed consent

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Plan for the next increase: Each jump can cause temporary side effects

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