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1.3% with metformin 1,000 mg twice daily

After 28 days, two things have happened

Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus and chronic weight management

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If you have type 2 diabetes or obesity and are already considering a GLP-1 agent for metabolic reasons, then the potential brain benefits are a compelling additional advantage