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Nausea, looser or firmer stools, and reduced appetite show up most, and they cluster around dose increases rather than staying constant

The remaining authors declare that they have no conflict of interest

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In vitro studies revealed a dramatic increase in the number of cells expressing the intercellular adhesion molecule CD34 and an increase in the number of CD31 + cells with active esterase under the direct action of GLP-1, suggesting that endothelial progenitor cells expressing CD31 and CD34 endothelial progenitor cell markers may be targets of GLP-1 and participate in the regeneration process of damaged endothelium in emphysematous mice with heterotrophic insulin, 47 and thus in airway remodeling

GLP-1 is critical in appetite control, digestion, and blood sugar regulation