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Sources van Bloemendaal, L, J S ten Kulve, S E la Fleur, R G Ijzerman, and M Diamant
(2019) Gutderived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition
Should symptoms persist despite these measures, short-term symptomatic pharmacotherapy targeting the specific gastrointestinal disturbance may be warranted [78]
Diabetes Res Clin Pract 2023
By combining GLP-1mediated appetite control with glucagon-driven metabolic stimulation, mazdutide aims to achieve greater and more durable reductions in body weight, particularly through loss of adipose tissue rather than lean mass
