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Recent data from LLY on Retatrutide (as well as other promising solutions presented at the American Diabetes Association conference) have made me consider something that seems inevitable on the surface, but the timeline of which may be greatly accelerated: obesity may have a cure (specifically - diabesity, the word for diabetes and obesity as comorbidities) in these new medications

A Nature-published study using molecular modelling and receptor-binding studies provided structural insights into retatrutide's simultaneous agonism at GLP-1R, GIPR, and GCGR, confirming that retatrutide binds all three as a single molecule without losing potency at any individual receptor

[DOI] [PubMed] [Google Scholar] 4.Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA

In another systematic review that included individuals with T2D from 38 phase III or IV placebo-controlled randomized controlled trials with GLP-1RAbased therapy (16), nausea was reported in 19.3% of participants with active treatment versus 6.5% with placebo, and vomiting was reported in 7.6% of participants versus 2% with placebo

Together, you can create a plan of action to help you reach and maintain a healthy weight