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Some patients experience mild nausea or gastrointestinal discomfort during the first few weeks, but these symptoms typically improve as your body adjusts

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Semaglutide and tirzepatide have largely replaced liraglutide due to superior effectiveness and once-weekly dosing

NEJM, July 2025 Source: SURMOUNT-5 NEJM 2025 (safety data) Source: MHRA Updated semaglutide guidance (GOV.UK, February 2026) The content on the SheMed blog is provided for general informational and educational purposes only

The thing is, retatrutide is currently in phase 3 clinical trials and is not yet FDA approved