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However, back pain was reported in SURPASS trial data at rates above 3% in some groups

Volume depletion and drug-drug interactions While GLP-1 RAs are generally well tolerated and are not associated with hypotension to the extent seen with traditional antihypertensive drugs, 81 their natriuretic effects may contribute to mild volume depletion

400 Researchers have discovered that GLP-1RAs exhibit a noticeable increase in the level of phosphorylated ERK1/2 within the sciatic nerve of diabetic rats

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