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Fukuda G, Yoshida T, Hirayama A, Umezawa Y, Takemoto M (2019) Dulaglutide-related bullous pemphigoid in a patient with type 2 diabetes: a case report

doi: 10.1016/j.cmet.2022.09.022

Evolution of Longer-Acting Formulations Once the chemistry was established, the next mission scientists faced was to make GLP-1 agonists last longer in the body, so patients wouldnt have to keep poking themselves like a pincushion

The primary mechanism of action involves stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

At the conclusion of this trial, the liraglutide-treated group exhibited a significant reduction in HbA1c level by about 1.12% compared to the exenatide group, which had 0.79% reduction
