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Additionally, we highlight the gaps for further studies in clinical applications of GLP-1 RAs in aging-related diseases

Conclusions/interpretation Our findings do not support an increased risk of SIS when taking GLP-1RA in individuals with type 2 diabetes and obesity

Due to a short plasma half-life of native GLP-1, several synthesized GLP-1 receptor agonists (RAs) were developed for type 2 diabetes mellitus (DM) treatment

these signals are hypothesis-generating and should not be interpreted as confirmed causal risks

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