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STEP 4 Investigators

While a high-fiber diet was able to increase the density of L cells and proglucagon mRNA levels in the colon of obese and leptin-deficient mice (Everard et al., 2011)
Research is mixed, but a 2025 systematic review reported that microbiome interventions (e.g., probiotics) generally improved body weight, body fat percentage, and metabolic parameters (e.g., lipid levels, glucose metabolism) in people with obesity

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Go lighter on fiber at night
