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This review consolidates the mechanistic basis and translational potential of GLP-1RAs in age-related neurodegenerative diseases, highlighting both their promise and the challenges that must be addressed in future clinical applications

They tolerate medications well and want the largest evidence-based weight reduction available

Whilst danuglipron is not available, UK patients can access MHRA-approved GLP-1 treatments such as semaglutide (Wegovy) and liraglutide (Saxenda) through NHS specialist weight management services, subject to NICE eligibility criteria and supply availability

A unique phenotype of obese HFpEF has been identified, which is associated with reduced exercise capacity (decreased peak VO 2 ) [122, 123], higher filling pressures in both left and right ventricles during exercise [5], as well as worse NYHA class, and even worse quality of life [123]

The interaction between retatrutide and other compounds is not well characterized outside of clinical trial settings