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On the one hand, secondary BAs activate Takeda G protein-coupled receptor 5 (TGR5) on intestinal L cells to stimulate GLP-1 secretion (70, 71)
How Non-Diabetic Weight Loss Differs From Diabetes Management In non-diabetic patients, GLP-1 receptor agonists work primarily through appetite suppression and improved satiety signaling in the brain, rather than correcting hyperglycemia
Goicoechea M, Garcia de Vinuesa S, Quiroga B, et al
