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Patient factors that may influence susceptibility to gastrointestinal symptoms include baseline gastrointestinal function, dietary habits, concurrent medications, and pre-existing conditions such as irritable bowel syndrome

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These findings support the use of retatrutide in laboratory studies examining how coordinated GLP-1R, GIPR, and GCGR activation affects hepatic metabolic regulation [5][8]

Both forms work through the same underlying mechanism

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