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Pharmacokinetics of GLP-1 Receptor Agonists Native GLP-1 has limited clinical applications due to its labile nature, with rapid degradation by the dipeptidyl peptidase-4 (DPP-4) enzyme contributing to a short plasma half-life of two minutes [17]

The company also offers a patient assistance program for low-income individuals, though eligibility criteria and available supply have been subject to change

Recently, the results of a landmark randomized controlled trial showed treatment with tirzepatide (15 mg subcutaneous/week), a dual GLP-1R/GIP receptor (GIPR) agonist, caused an 18% placebo-subtracted weight loss (21% total weight loss) at 72 weeks in people with obesity (6)

SP: Signal peptide

While these findings have not been conclusively observed in humans, the FDA has issued warnings about the potential risk