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There is a significant link between NAFLD and an increased risk of new-onset heart failure, regardless of the presence or absence of Type 2 diabetes and other associated cardiometabolic risk factors

The SELECT trial has shown reduction in major adverse cardiovascular events
Insulin and insulin-like growth factor 1 (IGF-1) are thought to play a role in promoting this condition, as their receptors are present on keratinocytes and fibroblasts

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