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According to American Diabetes Association guidelines, diabetes is diagnosed when A1C 6.5%, fasting plasma glucose 126 mg/dL, 2-hour plasma glucose 200 mg/dL during an oral glucose tolerance test, or random plasma glucose 200 mg/dL with classic symptoms

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The underlying pathogenesis seems to be related to an inflammatory response to foreign microcapsules due to a potential deficiency of enzymes needed to break down the poly-(d,l-lactide- co -glycolide) material into lactic and glycolic acid [58,59,60]

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