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It is possible that GLP-1-mediated metabolic or inflammatory improvements interact differently with female neuroendocrine physiology, leading to greater observable benefit in women, said White

After initiation of JANUVIA, patients should be observed carefully for signs and symptoms of pancreatitis

However, controversy still exists as to whether it is best to therapeutically promote or inhibit GIP action for beneficial effects on glycemic control and body weight [[929], [930], [931]] as both GIPR agonists [932] and antagonists [933,934] have decreased body weight in preclinical studies as individual treatments, but also to induce synergistic body weight loss when combined with GLP-1R agonists

Wilmouth, J

Is your weight plateauing because you need a dose adjustment, or is it because your medication has lost its strength