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Description
An open-label, single-center, case-control pilot study investigated the effects of GLP-1RAs in individuals with idiopathic intracranial hypertension (IIH) and obesity (BMI 30 kg/m) [98] (Fig

Some researchers have moved their eyes to small-molecule GLP-1RA - with high oral bioavailability, and high patient compliance
Just how much of a challenge this posed can be gauged from the fact that Mutt's group needed 10km of porcine small intestine to obtain about 1mg of pure secretin (Rehfeld 2012)
Proposed mechanisms include indirect effects via weight loss and reduced inflammation, though no direct electrophysiological action on atrial tissue has been established

Estimated fat-free mass may be best for determining protein needs, although there is still no consensus on the optimal approach